Just Pinned to Domestic and Global News: HIV eliminated from animals in 'humanized model'... "During acute infection HIV actively replicates" explained co-senior study investigator Kamel Khalili Ph.D. professor and chair of the department of neuroscience at LKSOM "With EcoHIV mice we were able to investigate the ability of the CRISPR/Cas9 strategy to block viral replication and potentially prevent systemic infection." The excision efficiency of their strategy reached 96 percent in EcoHIV mice providing the first evidence for HIV-1 eradication by prophylactic treatment with a CRISPR/Cas9 system. In the third animal model a latent HIV-1 infection was recapitulated in humanized mice engrafted with human immune cells including T cells followed by HIV-1 infection. "These animals carry latent HIV in the genomes of human T cells where the virus can escape detection Dr. Hu explained. Amazingly after a single treatment with CRISPR/Cas9 viral fragments were successfully excised from latently infected human cells embedded in mouse tissues and organs. In all three animal models the researchers employed a recombinant adeno-associated viral (rAAV) vector delivery system based on a subtype known a
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